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Year : 2016  |  Volume : 43  |  Issue : 4  |  Page : 190-195

Study of the association between nailfold capillaroscopic changes and serum level of interleukin-17 in rheumatoid: a clue for emerging vaculitis

1 Department of Physical Medicine, Rheumatology and Rehabilitation, New Miami, Alexandria, Egypt
2 Department of Internal Medicine, New Miami, Alexandria, Egypt
3 Department of Clinical Pathology, New Miami, Alexandria, Egypt

Correspondence Address:
Omneya E Elazzay
New Miami, Alexandria
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-161X.192254

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Objectives The aim of this work was to study nailfold capillaroscopic (NC) abnormalities and serum interleukin-17 (IL-17) level among rheumatoid arthritis (RA) patients and to find whether IL-17 is causally involved in the changes in the capillary vascular bed, such as autoimmune prevasculitic changes. Patients and methods The study was conducted on a group of RA Egyptian patients (n=40) who were diagnosed as having RA based on ACR criteria. Those 40 patients were further divided into two groups. Group 1 included RA patients with clinical signs of skin vasculitis and NC changes (n=6). Group 2 included RA patients with no clinical signs of skin vasculitis and no NC changes (n=34). All patients were subjected to demographic data collection, clinical examination, disease activity score 28 calculation, laboratory measurement (including erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, antinuclear antibody, antineutrophil cytoplasmic antibody, anti-cyclic citrullinated peptide, and IL-17) and NC examination. In addition, group 1 (n=6) was further subjected to electrophysiological evaluation using peripheral nerve conduction studies to determine the effect of vasculitis on the peripheral nerves. Results IL-17 level and NC changes showed a significant association in RA vasculitis patients. Conclusion Elevated levels of serum IL-17 and characteristic NC changes raise their importance in the detection of preclinical rheumatoid vasculitis.

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