Egyptian Rheumatology and Rehabilitation

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 42  |  Issue : 3  |  Page : 137--144

Validity of magnetic resonance image and HLA-B27 in early detection of sacroiliitis in Egyptian spondyloarthropathic patients


Rawhya R El-Shereef1, Amal Ali1, Ayman Darwish1, Fatma Ali1, Mohammed Ibrahim2, Lamia Hamdy2 
1 Department of Rheumatology and Rehabilitation, Faculty of Medicine, Minia University, Al-Minia, Egypt
2 Department of Radiology, Faculty of Medicine, Minia University, Al-Minia, Egypt

Correspondence Address:
Rawhya R El-Shereef
Department of Rheumatology and Rehabilitation, Faculty of Medicine, Minia University, Al-Minia
Egypt

Objective The aim of this study was to compare the validity of MRI in the early detection of sacroiliitis with laboratory findings of human leukocyte antigen-B27 (HLA-B27), conventional radiography, and clinical assessment. Participants and methods Sixty patients with spondyloarthropathy (group II) with duration of illness less than 2 years and 20 healthy controls (group I) were included in this study. Both groups were subjected to assessment of history, clinical examination, and laboratory investigations (erythrocyte sedimentation rate, C-reactive protein titer, rheumatoid factor, HLA-B27). Conventional radiography and MRI of the sacroiliac joints were performed. Spondyloarthropathic patients were divided according to MRI as follows: group IIA, which included patients with sacroiliitis, and group IIB, which included patients without sacroiliitis. Results In our study, ankylosing spondylitis was diagnosed in 22 (36.6%) patients, followed by undifferentiated spondyloarthropathy in 12 (20%) patients, reactive arthritis in 10 (16.7%) patients, psoriatic arthropathy in 10 (16.7%) patients, and enteropathic arthropathy in six (10%) patients. Evidence of sacroiliitis was found in 66.6% (40/60) of patients by MRI, which was higher than the result obtained by plain radiography 20% (12/60). HLA-B27 positivity found in 53.3% (32/60) of patients. There was a significant difference between the two groups in HLA-B27 and radiological sacroiliitis; there was no sacroiliitis in the control group. MRI showed sacroiliitis even in patients with no inflammatory back pain. There was a highly statistically significant difference between patient subgroups in disease duration (P = 0.001) and primary complaints and clinical sacroiliitis (P = 0.001). Conclusion MRI is the preferred modality in the detection of early sacroiliitis in spondyloarthropathy and HLA-B27 positivity is a highly useful predictor of early sacroiliitis


How to cite this article:
El-Shereef RR, Ali A, Darwish A, Ali F, Ibrahim M, Hamdy L. Validity of magnetic resonance image and HLA-B27 in early detection of sacroiliitis in Egyptian spondyloarthropathic patients.Egypt Rheumatol Rehabil 2015;42:137-144


How to cite this URL:
El-Shereef RR, Ali A, Darwish A, Ali F, Ibrahim M, Hamdy L. Validity of magnetic resonance image and HLA-B27 in early detection of sacroiliitis in Egyptian spondyloarthropathic patients. Egypt Rheumatol Rehabil [serial online] 2015 [cited 2020 Dec 2 ];42:137-144
Available from: http://www.err.eg.net/article.asp?issn=1110-161X;year=2015;volume=42;issue=3;spage=137;epage=144;aulast=El-Shereef;type=0