Egyptian Rheumatology and Rehabilitation

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 42  |  Issue : 3  |  Page : 145--152

Vitamin D receptor gene polymorphism in rheumatoid arthritis and its association with atherosclerosis


Amal M El-Barbary1, Manal S Hussein1, Elsayed M Rageh1, Salwa A Essa2, Hossam A Zaytoun3 
1 Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Tanta University, Tanta, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt
3 Department of Radiology, Faculty of Medicine, Tanta University, Tanta, Egypt

Correspondence Address:
Manal S Hussein
Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Tanta University, Tanta
Egypt

Aim of the work Determine vitamin D receptor gene BsmI, FokI polymorphism and 25-hydroxyvitamin D in early Egyptian rheumatoid patients and its association to subclinical atherosclerosis. Patients and methods This study included forty early rheumatoid arthritis patients and forty healthy controls. Disease activity score 28 (DAS-28), Modified Health Assessment Questionnaire (MHAQ), Carotid intima-media thickness (cIMT) were assessed using B-mode ultrasound, Erythrocyte sedimentation rate (ESR), C reactive protein (CRP), Lipid profile, anti cyclic citrullinated PolyPeptid (anti-CCP), serum interleukin-6, Total serum vitamin D and genotype determination of BsmI, FokI polymorphism and allel frequency were measured. Results Vitamin D deficiency was observed in 25% of patients. There was no significant difference between RA patients and controls regarding the distribution of BsmI genotype frequencies and allele. However, a significant difference between rheumatoid arthritis patients and controls regarding the distribution of FokI genotype and allele frequencies was found. In addition, FokI polymorphism and the F allele was significantly associated with RA. anti-CCP, interleukin-6 levels, (cIMT) and vitamin D deficiency were significantly higher in the presence of bb homozygote of BsmI genotypes and FF homozygote of FokI genotypes. A significant negative correlation between 25 hydroxy vitamin D levels with (DAS-28), ESR, (CRP), and IL-6 (P < 0.001). However, there was positive correlation between 25 hydroxyvitamin D levels and HDL-C (P < 0.001).


How to cite this article:
El-Barbary AM, Hussein MS, Rageh EM, Essa SA, Zaytoun HA. Vitamin D receptor gene polymorphism in rheumatoid arthritis and its association with atherosclerosis.Egypt Rheumatol Rehabil 2015;42:145-152


How to cite this URL:
El-Barbary AM, Hussein MS, Rageh EM, Essa SA, Zaytoun HA. Vitamin D receptor gene polymorphism in rheumatoid arthritis and its association with atherosclerosis. Egypt Rheumatol Rehabil [serial online] 2015 [cited 2020 Dec 2 ];42:145-152
Available from: http://www.err.eg.net/article.asp?issn=1110-161X;year=2015;volume=42;issue=3;spage=145;epage=152;aulast=El-Barbary;type=0